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. 2017 Aug 29;7:9902. doi: 10.1038/s41598-017-09921-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Osteoblast proliferation, differentiation and function is compromised in patDp/+ mice. (A) BrdU incorporation assay in +/+ and patDp/+ calvarial osteoblasts. (B) Real-time PCR analysis of Cyclins in WT and patDp/+ calvarial osteoblasts. (C) Alkaline phosphatase activity assay in +/+ and patDp /+ calvarial osteoblasts. (D) Real-time PCR analysis of osteoblast marker genes in +/+ and patDp/+ osteoblasts. (E) Alizarin red staining in +/+ and patDp/+ calvarial osteoblasts cultured for 21 days. (F,G) Trap staining analysis (F) and Trap gene expression (G) in differentiated osteoclasts from +/+ and patDp/+ mice. *P < 0.05. Values are mean ± SEM. n = 5–8 per group.