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. 2017 Aug 29;7:9605. doi: 10.1038/s41598-017-09867-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Canonical Wnt signalling and tcf7l2 expression in the pancreas. (A,B) Single and double fluorescent WISH comparing the expression of tcf7l2 and insulin at 7 dpf. Images show confocal single planes at 7 dpf at different magnification of (A) (20x) and (B,B’,B”) (60x). Merging the green and red channels identifies regions with distinct gene expression of the two genes (B’,B”). in: intestine, e: exocrine tissues, i: principal islet. Scale bar = 100 μm. (C) Expression level (count normalized by library size) obtained by RNAseq of different Tcf/Lef genes in α, β, δ and acinar cells from adult zebrafish. (D) tcf7l2 and egfp expression values from 10 different tissues derived from transgenic Tg(fli1a:EGFP)^y1 adult fish. Brain (Br), Eye (Ey), Gills (Gi), Gut (Gu), Heart (He), Kidney (Ki), Muscle (Mu), Pancreas (Pa), Vessels (Ve). (E) Enrichment of GFP⁺ cells from Tg(fli1a:EGFP)^y1 zebrafish embryos. Relative expression of indicated genes, in GFP⁺ (green bars) and GFP⁻ (grey bars) cells, determined by quantitative RT-PCR. Relative expression levels were determined by normalization to arp. Values represent the mean ± SEM. Asterisk above column indicate statistical differences among groups.