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. 2017 Aug 29;7:9748. doi: 10.1038/s41598-017-09619-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targeted metabolomics. Metabolites whose concentration (μM) is significantly different between responsive (R) and non-responsive (NR) patients at T2 (Wilcoxon rank-sum test p-value < 0.05, FDR < 0.15). The figure shows only 6 out of 23 metabolites (see Table 4) significantly differing in the two groups at T2 as example. Distributions are shown as box-plots where the central line is the median concentration, the edges of the box are the 25th and 75th percentiles and the outliers are defined as 1.5 times the interquartile range and highlighted by +.