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. 2017 Aug 29;7:9748. doi: 10.1038/s41598-017-09619-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targeted metabolomics. Metabolites whose concentration (μM) from T1 to T2 in the two groups is statistically different. The figure shows only 4 metabolites as an example of those differing overtime (see Table 5). Box-plots in the top right corner show the differences in metabolite concentrations between T1 and T2, expressed as delta (Δ = T2 − T1). We did the Wilcoxon rank-sum test for the delta of the two groups and Wilcoxon signed rank between T1 and T2 in each group separately. Significant differences are marked with *(p-value < 0.05).