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. 2017 Aug 29;7:9748. doi: 10.1038/s41598-017-09619-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma sPLA2-IIA levels (μg/L) in responsive (R) and non-responsive (NR) patients at T1 and T2 (panel A) and comparison of time trend variation, expressed as delta (Δ = T2 − T1), between the two groups (panel B). Distributions are shown as box-plots where the central line is the median concentration, the edges of the box are the 25th and 75th percentiles and the outliers are defined as 1.5 times the interquartile range and highlighted by +. Significant differences between groups are marked with *(Wilcoxon rank-sum test p-value < 0.05), whereas significant differences from T1 to T2 are marked with **(Wilcoxon sign-rank test p-value < 0.05).