Table 2.
Mortality and length of stay, comorbities, sources of infection and partial SOFA scores in the two groups (R: responsive; NR: not responsive to therapy).
| All Patients | R | NR | |
|---|---|---|---|
| Mortality | |||
| 7 days mortality [No (%)] | 1 (5%) | 0 (0%) | 1 (14%) |
| 28 days mortality [No (%)] | 5 (24%) | 2 (14%) | 3 (43%) |
| In hospital mortality [withdrawal of care] | 4 [3] (19% [14%]) | 1 [1] (7%) | 3 [2] (43% [23%]) |
| Length of stay in ICU before discharge (days)¶ | 5 (3.25, 9) | 4 (3, 6) | 10 (5, 10) |
| Total length of stay in hospital (days)¶ | 21.5 (11, 32.5) | 15 (11, 30) | 33 (24.75, 42) |
| Comorbidities | |||
| Acute Heart Failure [No (%)] | 12 (57%) | 7 (50%) | 5 (71%) |
| Acute Myocardial Infarction [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Prolonged arrhythmias [No (%)] | 4 (19%) | 1 (7%) | 3 (43%) |
| Chronic Organ Insufficiency [No (%)] | 19 (91%) | 13 (93%) | 6 (87%) |
| Arterial Hypertension [No (%)] | 9 (43%) | 5 (36%) | 4 (57%) |
| Diabetes Mellitus [No (%)] | 8 (38%) | 6 (43%) | 2 (23%) |
| Coronary arteries diseases [No (%)] | 2 (10%) | 1 (7%) | 1 (14%) |
| Systolic heart failure [No (%)] | 1 (5%) | 0 (0%) | 1 (14%) |
| Diastolic heart failure [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Cerebrovascular Disease [No (%)] | 2 (10%) | 2 (14%) | 0 (0%) |
| Peripheral vascular disease [No (%)] | 1 (5%) | 1 (7%) | 0 (0%) |
| Dementia [No (%)] | 2 (10%) | 2 (14%) | 0 (0%) |
| Chronic Lung Disease [No (%)] | 3 (14%) | 1 (7%) | 2 (23%) |
| Rheumatic/connective tissue disease [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Inflammatory Bowel Disease [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Peptic ulcer [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Mild liver disease [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Moderate/severe liver Disease [No (%)] | 2 (10%) | 1 (7%) | 1 (14%) |
| Chronic Kidney Disease [No (%)] | 0 (0%) | 0 (0%) | 0 (0%) |
| Tumor without metastasis [No (%)] | 2 (10%) | 1 (7%) | 1 (14%) |
| Hemiplegia/paraplegia [No (%)] | 1 (5%) | 1 (7%) | 0 (0%) |
| Source of Infection | |||
| Respiratory [No (%)] | 5 (24%) | 3 (21%) | 2 (23%) |
| Abdominal [No (%)] | 7 (33%) | 3 (21%) | 4 (57%) |
| Urinary Tract [No (%)] | 6 (29%) | 5 (36%) | 1 (14%) |
| Others [No (%)] | 3 (14%) | 3 (21%) | 0 (0%) |
| Therapies | |||
| Beta-blocker [No (%)] | 3 (14%) | 2 (14%) | 1 (14%) |
| Ionotropic Drugs [No (%)] | 7 (33%) | 4 (29%) | 3 (43%) |
| Sedation drugs [No (%)] | 21 (100%) | 14 (100%) | 7 (100%) |
| Other drugs [No (%)] | 19 (91%) | 14 (100%) | 5 (71%) |
| Tracheal Intubation [No (%)] | 19 (91%) | 13 (93%) | 6 (87%) |
| Renal Replacement Therapy [No (%)] | 1 (5%) | 1 (7%) | 0 (0%) |
| Transfusion [No (%)] | 2 (10%) | 0 (0%) | 2 (23%) |
| Partial Sofa Scores | |||
| Respiratory System | 3 (2, 3) | 3 (2, 3) | 3 (2, 3) |
| Nervous System | 4 (3.75, 4) | 4 (4, 4) | 4 (3.25, 4) |
| Cardiovascular System | 4 (3.75, 4) | 4 (3, 4) | 4 (4, 4) |
| Liver | 1 (0, 2) | 1 (0, 1) | 1 (0.25, 2.75) |
| Coagulation | 0 (0, 1.25) | 0 (0, 1) | 1 (0, 2.5) |
| Renal System | 1 (0.75, 2) | 1 (0, 2) | 2 (1, 2.75) |
Data are presented as median, 25th and 75th percentiles or as frequency (%). No significant differences were found (p-value > 0.05, Wilcoxon rank-sum test for continuous variables, Fishers’ Exact Test for categorical variables). Despite this, NR had longer ICU stay and higher mortality. ¶Indicates that analyses were done on 19 patients (3 patients were excluded as they died in the ICU).