Table 3.
Metabolite peak intensities from T1 to T2 in the two groups (untargeted approach).
| Responsive to therapy (R) | Not responsive to therapy (NR) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T1 | T2 | Δ = T2 − T1 | T1 | T2 | Δ = T2 − T1 | ||||||
| Creatinine | 12116 (10211, 17348) | 11109 (8507, 13271) | * | −1797 (−3691, −377) | ↓ | § | 13371 (10815, 15693) | 13749(10223, 19343) | 792 (−557, 2907) | ↑ | |
| L-Arginine | 4780 (3369, 5930) | 6528 (5183, 7638) | 2113 (552, 3812) | ↑ | 3434 (3200, 4627) | 7275 (5063, 8561) | * | 2958 (1379, 3837) | ↑ | ||
| L-Acetylcarnitine | 14079 (7830, 17703) | 9163 (6284, 11268) | * | −4143 (−10588, 1024) | ↓ | 22939 (11352, 28847) | 14851 (9771, 19232) | * | −4307 (−12256, −2900) | ↓ | |
| L-Threonine | 1155 (819, 1518) | 1747 (1415, 2296) | * | 816 (−53, 1075) | ↑ | 1038 (823, 1518) | 1754 (1520, 2214) | * | 481 (238, 1005) | ↑ | |
| Taurine | 1302 (929, 1837) | 859 (729, 1264) | * | −282 (−486, −83) | ↓ | 1516 (1032, 1902) | 1095 (883, 1421) | −362 (−975, 44) | ↑ | ||
| Kynuramine | 1496 (1418, 1688) | 1732 (1589, 1776) | * | 122 (28, 285) | ↑ | 1381 (1233, 1481) | 1584 (1320, 1701) | 72 (−2.55, 254) | ↑ | ||
| L-Tyrosine | 874 (788, 1040) | 1181 (867, 1476) | * | 105 (22, 667) | ↑ | 927 (801, 1089) | 1167 (931, 1740) | 281 (194, 403) | ↑ | ||
| Citric acid | 26765 (16429, 33356) | 16942 (7661, 24011) | * | −7611 (−12761,−1338) | ↓ | 33185 (24219, 44715) | 27909 (22868, 32550) | −8845 (−12989, −1882) | ↓ | ||
| L-Lysine | 1133 (891, 1405) | 1491 (1280, 2053) | * | 336 (90, 1190) | ↑ | 1149 (840, 1626) | 1515 (1324, 1973) | * | 446 (254, 819) | ↑ | |
| Stearic acid | 37344 (32419, 58541) | 38207 (32244, 42399) | −3464 (−9555, 2738) | ↑ | 38710 (31144, 51784) | 28711 (26782, 32069) | * | −11046 (−14567, −6515) | ↓ | ||
| Myristic acid | 2145 (1463, 3917) | 1511 (972, 3111) | −457 (−1804, 284) | ↓ | § | 3217 (1971, 6396) | 1024 (816, 2326) | * | −1365 (−3421, −991) | ↓ | |
| Palmitoleic acid | 5130 (2286, 9028) | 4338 (1625, 5849) | −1586 (−4475, 1268) | ↓ | 5852 (4761, 11911) | 2271 (1798, 4542) | * | −3707 (−8859, −2472) | ↓ | ||
| Palmitic acid | 61453 (47464, 76280) | 58577 (48918, 61999) | −5683 (−18696, 5115) | ↓ | 68002 (52214, 96968) | 47928 (36302, 53361) | * | −21621 (−48579,−11540) | ↓ | ||
| Oleic acid | 46791 (31181, 92927) | 43499 (27535, 85340) | −11901 (−56910, 11496) | ↓ | § | 94476 (76885, 179484) | 42356 (24828, 65253) | * | −63747 (−87753,−33127) | ↓ | |
Significant differences between T1 and T2 are marked with *(Wilcoxon signed-rank test p < 0.05), §marks differences in the delta between R and NR (Wilcoxon rank-sum test p < 0.05). The arrows indicate whether the metabolite concentration at T2 is lower (↓) or higher (↑) than at T1.