Table 1.
Host Characteristics.
| Variable | Cases n(%) | Controls n(%) | P-value |
|---|---|---|---|
| Total | 46 | 62 | |
| Age at diagnosis, mean(SD) | 9.2(4.7) | 9.3(5.7) | 0.92 |
| Gender | |||
| Female | 21(46) | 32(52) | 0.54 |
| Male | 25(54) | 30(48) | |
| Race | |||
| White | 22(48) | 38(61) | 0.028 |
| Hispanic | 16(35) | 10(16) | |
| Black | 8(17) | 9(15) | |
| Other | 0(0) | 5(8) | |
| Chest radiation | |||
| No | 31(67) | 48(77) | 0.24 |
| Yes | 15(33) | 14(23) | |
| Cancer site | |||
| Sarcoma | 21(46) | 20(32) | 0.092 |
| Leukemia | 5(11) | 19(31) | |
| Lymphoma | 14(30) | 15(24) | |
| Other | 6(13) | 8(13) | |
| Anthracycline cumulative dose, mean(SD) | 319.5(111.5) | 273.9(157.6) | 0.10 |
| Follow-up time in years, mean(SD) | 21.2(11.2) | 15.7(7.6) | 0.0027 |
| Average EF% low*, mean(SEM) | 43.48(1.152) | 57.14(0.28) | < 0.0001 |
| Risk score, mean(SD) | 6.0(1.7) | 5.4(1.4) | 0.032 |
| Hypertension | |||
| No | 19(41) | 40(65) | 0.017 |
| Yes | 27(59) | 22(35) | |
*Average of two lowest EF% for each patient.