Table 4.
Risk Factors associated with 30-day mortality analyzed by multivariable Cox’s proportional hazard mode in hospital-acquired Clostridium difficile infection patients.
| Variable | B | Standard error | Wald chi-square | Hazard ratio | 95% CI | P value |
|---|---|---|---|---|---|---|
| Age ≥65 | 1.092 | 0.437 | 6.251 | 2.981 | 1.266–7.017 | 0.012 |
| Bloodstream infection concomitant to CDI | 1.262 | 0.437 | 8.332 | 3.532 | 1.499–8.321 | 0.004 |
| Fever >38·5 °C | 1.108 | 0.375 | 8.725 | 3.027 | 1.452–6.312 | 0.003 |
| Mechanical ventilation prior to developing CDI | 1.164 | 0.399 | 8.491 | 3.201 | 1.464–7.002 | 0.004 |
| Connective tissue disease | 1.710 | 0.704 | 5.895 | 5.531 | 1.391–22.000 | 0.015 |
| Macrolide | 2.320 | 0.769 | 9.099 | 10.174 | 2.254–45.929 | 0.003 |
| Albumin ≤2.5 g/dL | 1.370 | 0.536 | 6.534 | 3.935 | 1.376–11.250 | 0.011 |
Statistical analysis was performed using a multivariable Cox’s proportional hazard model. Variables entering the multivariate analysis were selected by binary analysis (Supplementary Table 3).