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. 2017 Aug 29;7:9789. doi: 10.1038/s41598-017-10763-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multiple tumor biomarkers-iFISH. (a) (CK/EpCAM)-iFISH performed on enriched triploid colon cancer cell shows CD45⁻/CK18⁺/EpCAM⁺. WBCs (red arrows) are CD45⁺/CK18⁻/EpCAM⁻. (b) Tri-marker-iFISH indicates that the diploid tumor cell (green arrow) is CD45⁻/CK18⁺/EpCAM⁺/Vimentin⁺. Two of diploid WBCs (red arrows) are CD45⁺/Vimentin⁺. (c) (HER2/EpCAM/Vimentin)-iFISH reveals diploid breast cancer cell CD45⁻/HER2⁺/EpCAM⁺/Vimentin⁺. The WBC attached to the tumor cell is CD45⁺/Vimentin⁺ (red arrow). (d) Two of aneuploid lung cancer cells are CD45⁻/PD-L1⁺/CK18⁺/Vimentin⁺ (pink arrows). Depicted WBCs (red arrows) are CD45⁺/PD-L1⁺/CK18⁻, and one of WBCs is strong vimentin⁺ (red arrow).