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. 2017 Aug 29;7:9723. doi: 10.1038/s41598-017-10097-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomic profile of mice skeletal muscle exposed to 2-day (2 H) and 10-day (10 H) hypoxia. Histograms of skeletal muscle metabolic changes in 2 H (grey bars) and 10 H (black bars) as detected by 2D-DIGE analysis (ANOVA coupled to Tukey’s multiple-group comparison test, n = 5, p < 0.01). Protein spots statistically altered are reported with the corresponding gene name and the degree of variation is expressed as a percent of spot volume variation in hypoxic mice versus controls. (A) Metabolic proteins grouped according to their function: energy transfer enzymes (Ckm, creatine kinase),glycogen metabolism enzymes (Pygm, glycogen phosphorylase; Pgm2, phosphoglucomutase), glycolytic enzymes (Eno3, enolase; Pkm, pyruvate kinase), TCA cycle/OXPHOS enzymes (Aco2, aconitate hydratase; Idh3a, isocitrate dehydrogenase 3; Ogdh, 2-oxoglutarate dehydrogenase; Dld dihydrolipoyl dehydrogenase; Sdha, succinate dehydrogenase flavoprotein; Ndufs1, NADH dehydrogenase (ubiquinone) Fe-S protein 1; Atp5b, ATP synthase subunit beta; Mdh1, cytoplasmic malate dehydrogenase). (B) Structural/contractile (Des, desmin; Vim, vimentin; Tubb4b, tubulin beta-2C chain; Myh4, myosin-4; Mybph, myosin-binding protein H; Tnnt3, troponin T fast; Tpm2, tropomyosin beta chain; Myl1, myosin light chain 1/3, skeletal muscle isoform (MLC 1F); Myl3, myosin light chain 3 (MLC 1 sb)), stress response (P4hb, protein disulfide-isomerase; Pdia3, protein disulfide-isomerase A3; Trim72, tripartite motif-containing protein 72; Hspa8, heat shock cognate 71 kDa protein; Hsp90ab1, heat shock protein 84b; Park7, protein DJ-1) and other proteins (Ca3, Carbonic anhydrase 3; Mb, myoglobin; Pvalb, parvalbumin alpha; Tufm, elongation factor Tu, mitochondrial; Immt, Immt protein; Fgb, fibrinogen beta chain; Fgg, fibrinogen gamma chain; Tf, serotransferrin; Alb, serum albumin).