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. 2017 Aug 29;7:9818. doi: 10.1038/s41598-017-10127-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Four modules that significantly associated with the time point. (A) Gene dendrogram showing the co-expression modules constructed by the WGCNA and labeled by colors; (B) Module-trait associations. Each row contains the corresponding correlation and p-value. And each of them was color-coded by correlation according to the color legend; (C) A scatter plot of gene significance (GS) for time vs. module membership (MM) in the turquoise, yellow, blue and red module. There were highly significant correlations between GS and MM in those modules; (D) Enriched biological processes for those modules.