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. 2017 Aug 15;9(8):3676–3686.

Figure 3.

Figure 3

FL118 inhibits the growth of CSCs derived from A549 and H460. A: The expression of survivin of A549 and H460 derived stem cells was examined by western blotting. GAPDH servers as the control. After treated with FL118 at 10 nM and 100 nM, the level of survivin was downregulated over time. B: Quantitative RT-PCR was used to quantify survivin mRNA expression in A549 and H460 derived stem cells after treated with FL118 for 48 h. *P<0.05. C: The cell viability was detected by CCK-8 assay. In comparison with cisplatin, FL118 shows greater inhibitory effect on A549 and H460 derived stem cells, #P<0.05. The A549 and H460 derived stem cells were more sensitive to FL118 than their parental cells, *P<0.05. AS: A549 derived stem cells. HS: H460 derived stem cells.