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. 2017 Aug 15;9(8):3816–3826.

Figure 3.

Figure 3

The HGF-induced invasion of MDA-MB-231 and MCF-7 breast cancer cells is partially suppressed by COX2 gene silencing. A, B: MDA-MB-231 and MCF-7 cells were transfected with pshRNA-HK and pshRNA-COX2. Total cell lysates was used for Western blot analysis. A lower level of COX2 protein was detected in the HGF+pshRNA-COX2 group (*P<0.05), but it was higher than control (*P<0.05). C: Knockdown of the COX2 gene inhibited the HGF-induced cell invasion of MDA-MB-231 and MCF-7 cells (*P<0.05 vs. HGF and HGF+pshRNA-HK groups), and there was no statistically significant difference between the pshRNA-HK-transfected breast cancer cell lines and the HGF group (**P>0.05).