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. 2017 Aug 15;9(8):3816–3826.

Figure 6.

Figure 6

The Akt/PI3K and p38 MAPK pathways participate in COX2 regulation of HGF-induced invasion and MMP-9 production. A and B: MDA-MB-231 and MCF-7 cells were incubated in the presence or absence of 60 ng/ml HGF plus 10 μM LY294002 (Akt/PI3K inhibitor) or/and 10 me SB202190 (p38 inhibitor). Cells were used in invasion assays as described in Materials and Methods. Micrographs demonstrate a random field from the lower chamber membrane under different conditions (100×). C and D: LY294002 and SB202190 decreased the HGF-induced expression of the MMP-9 protein. (*, P<0.05 vs. the control group; #, P<0.05 vs. the HGF and control groups; **, P<0.05 vs. the HGF, HGF+LY294002 or HGF+SB202190 groups).