Table III.
Comparison of scores in separate psychopathology categories of the NPI scale and the frequency and severity of symptoms in the group of subjects who converted to dementia (MCI-D) and those with a stable course (MCI-nD)
| Parameter | Mean MCI-Dn = 34 | Mean MCI-nDn = 41 | t | df | P-value | MCI-D SD | MCI-nD SD | F – variances | P – variances |
|---|---|---|---|---|---|---|---|---|---|
| Age | 78.79 | 75.76 | 1.44 | 73 | 0.16 | 8.40 | 9.67 | 1.33 | 0.41 |
| Delusions: | |||||||||
| Frequency* | 1.24 | 0.22 | 4.06 | 73 | < 0.001 | 1.46 | 0.61 | 5.66 | < 0.001 |
| Severity* | 0.82 | 0.17 | 3.86 | 73 | < 0.001 | 0.97 | 0.44 | 4.81 | < 0.001 |
| Frequency × severity* | 2.38 | 0.29 | 4.30 | 73 | < 0.001 | 2.91 | 1.01 | 8.38 | < 0.001 |
| Hallucinations: | |||||||||
| Frequency | 0.44 | 0.15 | 1.77 | 73 | 0.08 | 0.99 | 0.36 | 7.66 | < 0.001 |
| Severity | 0.32 | 0.15 | 1.44 | 73 | 0.15 | 0.68 | 0.36 | 3.65 | < 0.001 |
| Frequency × severity* | 0.79 | 0.15 | 2.09 | 73 | 0.04 | 1.95 | 0.36 | 29.71 | < 0.001 |
| Agitation/aggression: | |||||||||
| Frequency* | 1.47 | 0.41 | 4.77 | 73 | < 0.001 | 1.02 | 0.89 | 1.31 | 0.42 |
| Severity* | 1.32 | 0.22 | 7.37 | 73 | < 0.001 | 0.81 | 0.47 | 2.88 | < 0.001 |
| Frequency severity* | 2.38 | 0.46 | 5.73 | 73 | < 0.001 | 1.83 | 1.03 | 3.16 | < 0.001 |
| Depression/dysphoria: | |||||||||
| Frequency* | 1.35 | 0.51 | 4.29 | 73 | < 0.001 | 0.92 | 0.78 | 1.39 | 0.32 |
| Severity* | 1.38 | 0.39 | 5.18 | 73 | < 0.001 | 1.04 | 0.59 | 3.17 | < 0.001 |
| Frequency × severity* | 2.71 | 0.61 | 5.56 | 73 | < 0.001 | 2.13 | 1.05 | 4.13 | < 0.001 |
| Anxiety: | |||||||||
| Frequency* | 1.29 | 1.05 | 1.24 | 73 | 0.22 | 0.72 | 0.95 | 1.74 | 0.11 |
| Severity* | 1.26 | 0.66 | 4.09 | 73 | < 0.001 | 0.71 | 0.57 | 1.52 | 0.20 |
| Frequency × severity* | 1.85 | 1.17 | 2.42 | 73 | 0.02 | 1.16 | 1.26 | 1.19 | 0.61 |
| Elation/euphoria: | |||||||||
| Frequency | 0.56 | 0.39 | 1.01 | 73 | 0.32 | 0.79 | 0.67 | 1.39 | 0.32 |
| Severity | 0.50 | 0.37 | 0.87 | 73 | 0.39 | 0.71 | 0.62 | 1.29 | 0.44 |
| Frequency × severity | 0.71 | 0.51 | 0.82 | 73 | 0.41 | 1.03 | 1.00 | 1.06 | 0.86 |
| Apathy/indifference: | |||||||||
| Frequency | 1.26 | 1.10 | 0.60 | 73 | 0.55 | 1.21 | 1.20 | 1.02 | 0.94 |
| Severity | 0.97 | 0.71 | 1.20 | 73 | 0.23 | 1.06 | 0.84 | 1.57 | 0.17 |
| Frequency × severity | 2.38 | 1.71 | 1.06 | 73 | 0.29 | 3.19 | 2.34 | 1.86 | 0.06 |
| Disinhibition: | |||||||||
| Frequency* | 0.56 | 0.27 | 2.17 | 73 | 0.03 | 0.61 | 0.55 | 1.25 | 0.50 |
| Severity* | 0.76 | 0.22 | 3.60 | 73 | < 0.001 | 0.85 | 0.42 | 4.16 | < 0.001 |
| Frequency × severity* | 0.82 | 0.27 | 3.28 | 73 | < 0.001 | 0.90 | 0.55 | 2.71 | < 0.001 |
| Irritability/lability: | |||||||||
| Frequency* | 1.56 | 0.63 | 3.86 | 73 | < 0.001 | 1.11 | 0.97 | 1.30 | 0.42 |
| Severity* | 1.35 | 0.49 | 4.80 | 73 | < 0.001 | 0.81 | 0.75 | 1.19 | 0.60 |
| Frequency × severity* | 2.56 | 0.95 | 3.94 | 73 | < 0.001 | 1.93 | 1.61 | 1.43 | 0.28 |
| Motor disturbance: | |||||||||
| Frequency* | 0.88 | 0.37 | 2.48 | 73 | 0.02 | 1.01 | 0.80 | 1.59 | 0.16 |
| Severity* | 0.76 | 0.34 | 2.22 | 73 | 0.03 | 0.92 | 0.73 | 1.61 | 0.15 |
| Frequency × severity* | 1.53 | 0.68 | 2.14 | 73 | 0.04 | 1.85 | 1.57 | 1.38 | 0.33 |
| Night-time behaviors: | |||||||||
| Frequency* | 0.94 | 0.29 | 2.77 | 73 | 0.01 | 1.23 | 0.78 | 2.47 | 0.01 |
| Severity* | 0.68 | 0.20 | 2.88 | 73 | 0.01 | 0.91 | 0.51 | 3.19 | < 0.001 |
| Frequency × severity* | 1.62 | 0.39 | 3.08 | 73 | < 0.001 | 2.27 | 1.07 | 4.50 | < 0.001 |
| Appetite/eating: | |||||||||
| Frequency | 0.06 | 0.00 | 1.58 | 73 | 0.12 | 0.24 | 0.00 | 0.00 | 1.00 |
| Severity | 0.06 | 0.00 | 1.58 | 73 | 0.12 | 0.24 | 0.00 | 0.00 | 1.00 |
| Frequency × severity | 0.06 | 0.00 | 1.58 | 73 | 0.12 | 0.24 | 0.00 | 0.00 | 1.00 |
| NPI-Total* | 41.62 | 16.49 | 6.48 | 73 | < 0.001 | 19.83 | 13.63 | 2.12 | 0.02 |
*
Statistically significant differences (p < 0.05).