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. 2017 Aug 29;7:9860. doi: 10.1038/s41598-017-10253-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered functional networks in vitiligo. Network map of clusters of genes associated with vitiligo predisposition along with their interacting partners were mapped to the differential expression of genes observed in vitiligo. Three networks are shown: SCF-KIT signaling, oxidative stress and immune response. Each node (gene) is colored according to upregulation (red), downregulation (green), or no regulation (grey). White denotes proteins for which corresponding probes were not found in the microarray. The regulation score was calculated from microarray experiments performed on 15 vitiligo samples, where only agreement between >= 11 samples was included as a significant regulation.