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. 2017 Aug 29;7:9877. doi: 10.1038/s41598-017-09992-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of anesthetic properties with anesthetic potency. (a) Meyer-Overton correlation of oil:gas partition coefficient versus MAC (Blue points – anesthetics; Red points – non-anesthetics; Green points – anesthetic/convulsant; Red line – difference between non-anesthetic predicted and estimated (~1000% atm) MAC). (b) Correlation of polarizability versus MAC, with MAC for non-anesthetics determined from the Meyer-Overton correlation. (c) Correlation of polarizability versus solubility shows a difference in the relation between these properties for non-anesthetics and anesthetics. Trend lines and equations based on anesthetics alone, without the contributions from the non-anesthetics and anesthetic/convulsant.