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. 2017 Aug 29;7:9613. doi: 10.1038/s41598-017-10110-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Temporal variations of WF_h and WF_v in the (a) subcutaneous tissue and (b) muscle tissue, respectively. Insets are X-ray images of the subcutaneous and muscle tissues at 0 min and 10 min after drug injection. (c) Aspect ratios in the subcutaneous and muscle tissues at 0 min and 10 min after drug injection. Variations of RCS values according to distance from the needle in (d) the subcutaneous tissue and (e) the muscle tissue. Temporal variations of C_v in the (f) subcutaneous tissue and (g) muscle tissue, respectively. The C_v values are measured at the regions of SC, SWF_h, and SWF_v (insets, dotted boxes). Scale bar: 500 μm.