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. 2017 Aug 29;7:9709. doi: 10.1038/s41598-017-10648-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between DNA methylation and gene expression levels. The methylation level in the gene regions was estimated by the normalized read depth. In gene body, each gene was divided into 50 equal windows, and the average normalized depth was calculated for each window. The 2.2 kb regions upstream of TSS and downstream of TTS were divided into 20 non-overlapping windows, and the average normalized depth was calculated for each window. Genes were divided into four groups based on the ranking of average expression levels. Each line denotes the DNA methylation level of different gene expression groups. (A) Poly I:C-treated group; (B) untreated group.