Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 29;7:9815. doi: 10.1038/s41598-017-10168-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Protection against renal I/R injury by a FXR agonist. Mice were injected i.p. with 6-ECDCA before I/R injury. At 24 h after I/R, kidney, serum and urine samples were collected for measurements of (A) FXR target gene expression in kidney, (B) BUN in serum, (C) creatinine in serum. (D) Representative images showing HE staining on renal sections from (a) sham, (b) I/R, (c) I/R + ECDCA and (d) sham + ECDCA groups (scale bar 50 μm). (E) Representative images showing Kim1 immunostaining in renal sections from (a) sham, (b) I/R, (c) I/R + ECDCA and (d) sham + ECDCA groups (scale bar 50 μm). Kim1 is specifically localized in the proximal tubules. (F) Quantitative analysis of tubular injury scores. n = 6 mice/group. (G) Quantitative analysis of Kim1 positive staining per high power field. n = 6 mice/group. Data are means ± SEM, one-way ANOVA with Bonferroni’s test. *p < 0.05.