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. 2017 Aug 29;7:9815. doi: 10.1038/s41598-017-10168-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FXR mRNA expression is inversely correlated with CKD progression. (A) FXR mRNA expression in kidney samples from sham and I/R mice 16 wk after surgery. (B) FXR mRNA expression in human kidney biopsies was directly correlated with eGFR. (C) FXR mRNA expression in human kidney biopsies was inversely correlated with interstitial fibrosis, as determined by histology. The lowest level of FXR mRNA expression was set to 1 (shown as ). (D and E) Representative images of (D) Masson’s trichrome staining and (E) PAS staining in renal biopsy sections from (a) normal subjects and (b) patients with CKD (scale bar 20 μm). (F) immunostaining for FXR in renal biopsy sections from (a) normal subjects and (b) patients with CKD (scale bar 100 μm).

Inline graphic — FXR mRNA expression is inversely correlated with CKD progression. (A) FXR mRNA expression in kidney samples from sham and I/R mice 16 wk after surgery. (B) FXR mRNA expression in human kidney biopsies was directly correlated with eGFR. (C) FXR mRNA expression in human kidney biopsies was inversely correlated with interstitial fibrosis, as determined by histology. The lowest level of FXR mRNA expression was set to 1 (shown as ). (D and E) Representative images of (D) Masson’s trichrome staining and (E) PAS staining in renal biopsy sections from (a) normal subjects and (b) patients with CKD (scale bar 20 μm). (F) immunostaining for FXR in renal biopsy sections from (a) normal subjects and (b) patients with CKD (scale bar 100 μm).