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. 2017 Aug 29;7:9600. doi: 10.1038/s41598-017-08821-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scrapie infected hamsters show retinal iron imbalance. Neuroretinal lysates from mock and scrapie-infected hamsters were subjected to differential centrifugation to separate detergent-soluble and insoluble proteins, and processed for Western blotting. Probing for PrP reveals partitioning of most of the PrP^C from mock infected samples in the detergent-soluble phase (lanes 1 & 3), while the majority of PrP^Sc from infected samples partitions in the detergent-insoluble phase (lanes 2 & 4). Re-probing for Tf shows up-regulation in scrapie-infected samples, most of which partitions in the detergent-soluble phase (lanes 1–4). Re-probing for ferritin shows significant up-regulation in scrapie-infected samples, and partitioning of a significant amount in the detergent-insoluble phase (lanes 1–4; *non-specific reaction).