Table 2.

CRE: comparison of Carba-R, minimum inhibitory concentrations, and EPI-CRE assays, and susceptibility profiles.

Resistance		Organism	Detection Method
			CARBA-R		MIC OR MIC RANGE (µg/mL)a				EPI-CRE
Mechanismb
Designation	N		N	% POS	Doripenem	Ertapenem	Imipenem	Meropenem	N	% POS
IMI	3	Enterobacter cloacae	3	NA	2–>8	2.0–16.0	>8–>32	2–16	3	100
IMP 1	2	Enterobacter aerogenes	1	100	2	2	2	2	1	100
		Klebsiella pneumoniae	1	100	>2	>4	>8	>8	1	100
IMP 4	1	Klebsiella pneumoniae	1	NA	1	≤1	≤1	≤1	1	100
KPC	23	Klebsiella pneumoniae	12	100	0.5–<2	2–>4	≤1.0–>8	≤1.0–<8	12	100
		Escherichia coli	2	100	2–>2	4	4–8	4–8	2	100
		Enterobacter cloacae	3	100	2–8	4–>8	4–8	4–>8	3	100
		Proteus mirabilis	2	100	2–4	1–2	16	0.5–2	2	100
		Klebsiella oxytoca	1	100	0.5	0.5	4	1	1	100
		Kluyvera ascorbata	1	100	4	8	4	8	1	100
		Morganella morganii	1	100	4	8	8	4	1	100
		Raoultella ornithinolytica	1	100	2	1	4	1	1	100
KPC 2	4	Klebsiella pneumoniae	4	100	>2	>4–>16	4–16	4–>16	4	100
KPC 3	15	Escherichia coli	2	100	4	2–8	4	4	2	100
		Klebsiella pneumoniae	13	84.6 (2)c	≤0.12–>8	≤0.25–>16	≤1.0–>64	≤1.0–>16	13	100
KPC 4	1	Klebsiella pneumoniae	1	100	≤0.12	≤0.25	≤1.0	≤1.0	1	100
KPC+CTX-M-1	1	Enterobacter cloacae	1	100	4	>8	8	8	1	100
NDM+CTX-M-1	1	Escherichia coli	1	100	>8	>8	8	>8	1	100
NDM+OXA 232	1	Klebsiella pneumoniae	1	100	>8	>8	64	>8	1	100
NDM	19	Citrobacter freundii	1	100	>8	>8	16	>8	1	100
		Escherichia coli	7	100	>2–>8	>4–>16	8–32	8–>16	7	100
		Klebsiella pneumoniae	9	100	>2–>8	>4–>8	4–>64	8–>8	9	100
		Proteus mirabilis	1	100	>8	4	32	4	1	0
		Salmonella sv. Seftenberg	1	100	8	>8	4	8	1	100
NDM 1	2	Klebsiella pneumoniae	2	100	>8	>8	≤0.5–32	>8	2	100
NDM 5	2	Escherichia coli	2	100	>8	>8	16	>8	2	100
NDM 6	2	Escherichia coli	2	100	>2–>8	>4–>8	>8–16	>8	2	100
OXA 48	6	Klebsiella pneumoniae	6	83.3	>2–8	>4–>8	4–>8	8–>8	6	100
OXA 181	3	Klebsiella pneumoniae	3	100	2–4	8–>8	2–4	2–4	3	100
SME	7	Serratia marcescens	7	NA	>2	>4–>16	>8–>32	8–>16	7	0
VIM	2	Enterobacter cloacae	1	100	4	2	4	2	1	100
		Klebsiella pneumoniae	1	100	>8	>4	8	8	1	100
VIM 27	1	Klebsiella pneumoniae	1	100	>2	>4	>8	>8	1	100
Initial % +				96.5						91.7
Post DAd % +				100						91.7

^aOrganisms resistant (CLSI standards) to imipenem, meropenem, doripenem, ertapenem.

^bDetermined by routine PCR.

^cNot 100% sensitivity because organisms cured plasmid.

^dDA, discrepant analysis.