Table 2.
Overview of chemokine receptor‐ligand interactions on gingiva fibroblasts
| Receptor | Alias | Expressed | Ligand | Alias | Proliferation | Migration | IL‐6 | HGF | TIMP‐1 |
|---|---|---|---|---|---|---|---|---|---|
| CCR1 | CD191 | No | |||||||
| CCR2 | CD192 | No | |||||||
| CCR3 | CD193 | Yes | CCL5 CCL15 | RANTES | + | + | − | − | − |
| HCC‐2 | + | + | − | − | ‐‐ | ||||
| CCL28 | MEC | + | + | + | + | − | |||
| CCR4 | CD194 | Yes | CCL22 | MDC | + | + | + | − | − |
| CCR5 | CD195 | No | |||||||
| CCR6 | CD196 | Yes | CCL20 | MIP‐3α | − | + | − | − | − |
| CCR7 | CD197 | No | |||||||
| CCR8 | CDw198 | No | |||||||
| CCR9 | CDw199 | Yes | CCL25 | TECK | − | + | − | − | − |
| CCR10 | Yes | CCL27 CCL28 | CTACK | − | + | − | + | − | |
| MEC | + | + | + | + | − | ||||
| CXCR1 | CD181 | Yes | CXCL8 | IL‐8 | − | − | − | − | − |
| CXCR2 | CD182 | Yes | CXCL1 | GROα | − | + | − | − | − |
| CXCL8 | IL‐8 | − | − | − | − | − | |||
| CXCR3 | CD183 | No | |||||||
| CXCR4 | CD184 | Yes | CXCL12 | SDF‐1α | − | − | − | − | − |
| CXCR5 | CD185 | Yes | CXCL13 | BLC | − | + | − | − | − |
| CXCR6 | CD186 | No | |||||||
| CXCR7 | ACKR3 | Yes | CXCL11 | I‐TAC | − | + | − | − | − |
| CXCL12 | SDF‐1α | − | − | − | − | − | |||
| CX3CR1 | Yes | CX3CL1 | Fractalkine | − | + | + | − | − | |
| XCR1 | No | XCL1 | Lymphotactin α | + | + | − | − | − |
Chemokine receptors that were expressed on gingiva fibroblasts were stimulated with corresponding chemokine ligands to study proliferation, migration, and secretion of wound healing mediators. +indicates an increase compared to control, −indicates no difference from control, and ‐‐indicates a decrease compared to control.