Figure 5.

Prior corticosterone (CORT) treatment significantly increases phosphorylated signal transducer and activator of transcription 3 tyrosine 705 (pSTAT3^tyr705) levels in diisopropyl fluorophosphate (DFP) and chlorpyrifos oxon (CPO) treated mice. Effects of CORT pretreatment (400 mg/L, 1.2% EtOH) on the phosphorylation of STAT3 at 6 h following AChE inhibitor exposure. pSTAT3^tyr705 protein was measured in the cortex and hippocampus of saline, DFP, CPO, Pyridostigmine bromide (PB), and physostigmine (PHY) treated mice. Data represents mean ± SEM (N = 4–6 mice/group). Statistical significance of at least p ≤ 0.05 is denoted by * compared with relevant control (vehicle or CORT) and # compared within treatment (saline or AChE inhibitor).