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. 2017 May 31;69(9):1145–1154. doi: 10.1111/jphp.12752

Figure 4.

Figure 4

Influence of the dosing schedule of methotrexate on serum type II collagen antibody levels in collagen‐induced arthritis rats. Methotrexate was orally administered thrice weekly (2.33 mg/kg per time) and once daily (0.25 or 1.0 mg/kg) for 3 weeks. Sodium bicarbonate was administered to the normal group and collagen‐induced arthritis groups. Each value represents the mean ± SD (n = 6). ***P < 0.001 vs the collagen‐induced arthritis group, ### P < 0.001 vs the thrice‐weekly group, ††† P < 0.001 vs the 0.25 mg/kg once‐daily group. Serum type II collagen antibody levels were similar between the 0.25 mg/kg once‐daily (1.75 mg/kg per week) and 2.33 mg/kg thrice‐weekly (7 mg/kg per week) groups. Type II collagen antibody levels were below the detection limit in the 1.0 mg/kg once‐daily group, in which the inhibition of arthritis was the greatest.