Skip to main content
. 2017 Jul 28;9(8):97. doi: 10.3390/cancers9080097

Figure 2.

Figure 2

Altered VEGF-A localization following ablation of collagen, V.I. Immunostaining for VEGF-A (red) and CD31 (green) was used to quantify and localize VEGF-A sequestration in tumors from control (A) and collagen VI null (B) mice. Arrows identify VEGF-A closely associated with tumor blood vessels. Arrowheads identify VEGF-A distributed more diffusely in the tumor parenchyma. Non-vascular VEGF-A in collagen VI null tumors is increased 2-fold compared to control tumors (C). In contrast, vascular VEGF-A in collagen VI null tumors is reduced 2-fold compared to control tumors (D). Scale bar: 120 μm. * p < 0.05. † p < 0.05 versus 12-day wild type. ‡ p < 0.002 versus 7-day collagen VI null. Data taken from You et al. [24].