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Members of mammalian DNA methyltransferase (DNMT) families. (a) Structural comparison of all mammalian DNMTs; (b) function of each member for DNA methylation: initial CpG methylation (de novo) is established by the DNMT3 family, while it is maintained by another DNMT family (DNMT1). * DNMT2 is an example of divergent evolution and methylates the tRNAAsp anticodon loop at Cys38.
