(A) Tumors were enumerated in each strain following oil, MCA/oil, or MCA/BHT treatment (protocol 2). Mean ± SEM presented for tumor multiplicity or the number of tumors per mouse; Ereg+/+ mice (MCA/oil, n = 9; MCA/BHT n=19); Ereg−/− mice (MCA/oil n=5; MCA/BHT n=15). No tumors were observed in either strain with oil alone (n=3 per strain). *, p<0.05 for BHT compared to oil controls; +, p<0.05 for Ereg+/+ mice compared to Ereg−/− mice. (B) Tumor sizes evaluated using a digital caliper did not differ between strains in response to MCA/BHT. Ereg+/+ mice n = 130 tumors; Ereg−/− mice n = 35 tumors.