Table 3.
Blood Lipid Profile and Glucose Levels
| A. | ||||
|---|---|---|---|---|
| Male | Total Cholesterol (mg/dL) | HDL (mg/dL) | TG (mg/dL) | Glucose (mg/dL) |
| C57Bl6 | <100 | 61.8 ± 9.68 | 46.3 ± 1.08 | 188.4 ± 9.1 |
| [Tg(CAT)+/−] | <100 | 64.8 ± 2.38 | 95.3 ± 15.9a* | 220.1 ± 14.1 |
| Bob-Cat | <100 | 65.8 ± 4.56 | 47.5 ± 0.9b# | 203.4 ± 7.3 |
| Ob/Ob | 150 ± 7.49d*#$ | 98.8 ± 1.08a#$, b* | 67.5 ± 8.5 | 319.8 ± 27.1a#, b*$ |
| B. | ||||
|---|---|---|---|---|
| Female | Total Cholesterol (mg/dL) | HDL (mg/dL) | TG (mg/dL) | Glucose (mg/dL) |
| C57Bl6 | <100 | 48.63 ± 3.45 | 47.4 ± 2.22 | 192.9 ± 13.0 |
| [Tg(CAT)+/−] | <100 | 51.42 ± 3.2 | 50.2 ± 2.72 | 225 ± 9.0 |
| Bob-Cat | <100 | 47.45 ± 2.93 | 54.8 ± 3.27 | 176.3 ± 12.4 |
| Ob/Ob | 119.4 ± 3.8d*#$ | 93.43 ± 3.87d*#$ | 80.3 ± 9.23c*# | 367.8 ± 44.6d*#$ |
Lipid Profile and glucose were determined in blood obtained from both male and female mice of all genotypes on a Cholestech kit: (A) Total Cholesterol, High Density Lipoprotein (HDL), Triglyceride (TG), and Glucose levels in C57Bl6, [Tg(CAT)+/−], Bob-Cat, and Ob/Ob mice (n≥4/group) (B) Total Cholesterol, High Density Lipoprotein (HDL), Triglyceride (TG), and Glucose levels in C57Bl6, [Tg(CAT)+/−], Bob-Cat, and Ob/Ob female mice (n≥6/group). Data reported as mean +/− SEM and significant differences are displayed with letters indicating p values:
a
p<0.05,
b
p<0.01,
c
p<.001,
d
p<.0001; symbols represent significant differences between genotypes,
*
compared to C57Bl6,
#
compared to [Tg(CAT)+/−],
$
compared to BobCat.