Table 2.
| ||||
---|---|---|---|---|
entry | equivalent of 1b | solvent | equiv. of CsOAc | yieldb |
1 | 1 | DCE | 1 | trace |
2 | 1 | DMF | 1 | 58% |
3 | 1 | DMA | 1 | 61% |
4 | 2 | DMA | 1 | 68% |
5 | 2 | DMA | 0.5 | 67% |
6 | 3 | DMA | 1 | 87%(83%) |
Reactions were run with 1b, terephthalonitrile (0.1 mmol, 1 equiv), photocatalyst (3 mol %), base in 0.5 mL of solvent.
Yields were determined by 1H NMR analysis, and isolated yield is given in parentheses.