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Schematic model of the functions of neutrophil gelatinase-associated lipocalin (NGAL) (a) Siderophore–iron associated NGAL delivers iron into the cell in a megalin-dependent manner. After the uptake, NGAL traffics into the endosome from where iron is released. This results in a regulation of iron-responsive genes. (b) Siderophore-free NGAL captures siderophore-bound iron and transports it into the extracellular space.
