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Schematic model of the functions kidney injury molecule-1 (KIM-1). KIM-1 acts as a phosphatidylserine receptor and binds apoptotic cell bodies. KIM-1 binds to the alpha subunit of heterotrimeric G12 protein (Gα12), thereby mediating phagocytosis of apoptotic cell bodies. The extracellular domain of KIM-1 is shed from the cell surface by a metalloproteinase (MMP)-dependent process.
