Fig. 2.

PM_2.5 exposure stimulates BACE1 expression and impairs spatial learning and memory. a ELISA detection of Aβ42 content. (b1) Representative protein bands of immunoblot analysis for APP, BACE1, γ-secretase (nicastrin) and α-secretase (ADAM10). (b2) Quantification of APP, BACE1, γ-secretase (nicastrin) and α-secretase (ADAM10) expression. The data are presented as the means ± SE (n = 4 to 8 mice/group). c Swim velocity over 5 days of invisible training to find the hidden platform in the Morris water maze. d Learning curve over 5 days of invisible training to find the hidden platform in the Morris water maze. Retention memory was determined using a probe trial test conducted 24 h after 5 days of training. During the probe test, the platform was removed from the pool. e Number of times crossing the target zone. f Percentage of time spent in the target quadrant. The data are expressed as the means ± SE (n = 13 to 14 mice/group). */^# P < 0.05; **P < 0.01. Con = control group. Veh = vehicle control; Low = 1 mg/kg PM_2.5; High = 5 mg/kg PM_2.5。In all figures, unless stated otherwise, the dotted line crossing the y-axis at 1.0 represents data normalized to the control or vehicle control