Fig. 3.
PM2.5 exposure impairs functional synaptic integrity. (a1) Time courses of changes in the field excitatory postsynaptic potential (fEPSP) slope under different treatments. (a2) Mean values of the fEPSP slope averaged from 56 to 60 min after theta burst stimulation (TBS). The data are expressed as the means ± SE (n = 6 mice/group). (b1) Representative protein bands of immunoblot analysis for AMPA (GluA1 and GluA2) and NMDA (GluN1, GRIN2A, and GRIN2B). (b2) Quantification of AMPA (GluA1 and GluA2) and NMDA (GluN1, GRIN2A, and GRIN2B) receptor expression. (c1) Representative protein bands of immunoblot analysis for PSD-95. (c2) Quantification of PSD-95 expression. The data are expressed as the means ± SE (n = 4 to 8 mice/group). */# P < 0.05; **/## P < 0.01; ***/### P < 0.001. Con = control group. Veh = vehicle control; Low = 1 mg/kg PM2.5; High = 5 mg/kg PM2.5; High PM2.5 = 5 mg/kg PM2.5