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Principal ion channels expressed in vascular SMCs. In the plasma membrane (gray), the following channels are expressed: at least two members of the inward-rectifier K+ channel (KIR) family; large-conductance, Ca2+-activated K+ channels (KCa 1.1); at least six members of the voltage-dependent K+ channel (Kv) family; at least two voltage-dependent Ca2+ channels (Cav); and a number of TRP channels. In the endoplasmic reticular membrane (brown), RyRs and IP3R are expressed.
