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Published in final edited form as: Int J Neuropsychopharmacol. 2010 Mar 3;14(2):157–174. doi: 10.1017/S1461145710000179

Fig. 3 — Gene transcription pathways related to cell adhesion molecules. Genes in red were up-regulated whereas those in green were down-regulated at the mRNA level by gestation nicotine exposure in (a) the caudate putamen, (b) nucleus accumbens, (c) prefrontal cortex and (d) amygdala. * Significantly modified compared with gestational saline treatment (p<0.05 at least). APC, adenomatous polyposis coli; Axin, axin 1; B-Raf, v-raf murine sarcoma viral oncogene homolog B1; c-Raf, v-raf-1 murine leukemia viral oncogene homolog 1; C3G, Rap guanine nucleotide exchange factor 1; Calpain, M calpain; CAS, breast cancer anti-estrogen resistance 1; CNTN1, contactin 1; CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian)-like; Delta/Jagged, Notch ligand delta or jagged; Dsh, disheveled; FAK, PTK2 protein tyrosine kinase 2; Frizzled, frizzled homolog 1 (Drosophila); Fyn, FYN oncogene related to SRC, FGR, YES; GBP, frequently rearranged in advanced T-cell lymphomas; GRB2, growth factor receptor-bound protein 2; GSK3, glycogen synthase kinase 3; ILK, integrin-linked kinase; JNK1, mitogen-activated protein kinase 8; MKK4, mitogen-activated protein kinase kinase 4; MLCK, myosin light chain kinase; MLK3, mitogen-activated protein kinase kinase kinase 11; Notch, Notch gene homolog 1 (Notch 1); PAK, p21-activated protein kinase 1 (Pak1); PI3K, phosphatidylinositol 3-kinase; PP2A, protein phosphatase type 2a; R-Ras, related RAS viral (r-ras) oncogene homolog; RAP, RAS-related protein 1a; Ras, Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; SHC, SHC (Src homology 2 domain containing) transforming protein 1; SOS, son of sevenless homolog; Src, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); TACE, ADAM metallopeptidase domain 17; Wnt, wingless-type MMTV integration site family, member 1 (Wnt1); β-catenin, cadherin-associated protein, beta.

Fig. 3 — Gene transcription pathways related to cell adhesion molecules. Genes in red were up-regulated whereas those in green were down-regulated at the mRNA level by gestation nicotine exposure in (a) the caudate putamen, (b) nucleus accumbens, (c) prefrontal cortex and (d) amygdala. * Significantly modified compared with gestational saline treatment (p<0.05 at least). APC, adenomatous polyposis coli; Axin, axin 1; B-Raf, v-raf murine sarcoma viral oncogene homolog B1; c-Raf, v-raf-1 murine leukemia viral oncogene homolog 1; C3G, Rap guanine nucleotide exchange factor 1; Calpain, M calpain; CAS, breast cancer anti-estrogen resistance 1; CNTN1, contactin 1; CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian)-like; Delta/Jagged, Notch ligand delta or jagged; Dsh, disheveled; FAK, PTK2 protein tyrosine kinase 2; Frizzled, frizzled homolog 1 (Drosophila); Fyn, FYN oncogene related to SRC, FGR, YES; GBP, frequently rearranged in advanced T-cell lymphomas; GRB2, growth factor receptor-bound protein 2; GSK3, glycogen synthase kinase 3; ILK, integrin-linked kinase; JNK1, mitogen-activated protein kinase 8; MKK4, mitogen-activated protein kinase kinase 4; MLCK, myosin light chain kinase; MLK3, mitogen-activated protein kinase kinase kinase 11; Notch, Notch gene homolog 1 (Notch 1); PAK, p21-activated protein kinase 1 (Pak1); PI3K, phosphatidylinositol 3-kinase; PP2A, protein phosphatase type 2a; R-Ras, related RAS viral (r-ras) oncogene homolog; RAP, RAS-related protein 1a; Ras, Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; SHC, SHC (Src homology 2 domain containing) transforming protein 1; SOS, son of sevenless homolog; Src, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); TACE, ADAM metallopeptidase domain 17; Wnt, wingless-type MMTV integration site family, member 1 (Wnt1); β-catenin, cadherin-associated protein, beta.