Table 2.
Incidence rates (95% CI) and hazard ratios (95% CI) of coronary heart disease and strokes in relation to factor XI, the CHS Study, 1992 – 2013.
| Stroke | Factor XI quintiles, mg/dL
|
Continuous
|
|||||
|---|---|---|---|---|---|---|---|
| Q1 (8.0–92.4) |
Q2 (92.5–107.1) |
Q3 (107.1–120.3) |
Q4 (120.3–138.9) |
Q5 (139.0–400) |
PTREND | Per 1-SD (32.2 mg/dL) increment | |
| CHD | |||||||
| Events, n | 231 | 272 | 231 | 247 | 251 | ||
| Incidence rate† | 32.3 (28.4–36.7) | 37.3 (33.1–42.0) | 29.6 (26.0–33.7) | 31.7 (28.0–35.9) | 33.0 (29.2–37.3) | ||
| Model 1 HR | 1 (Referent) | 1.27 (1.07–1.52) | 1.07 (0.89–1.28) | 1.15 (0.96–1.38) | 1.27 (1.05–1.53) | 0.06 | 1.04 (0.98–1.10) |
| Model 2 HR | 1 (Referent) | 1.23 (1.03–1.48) | 1.02 (0.84–1.23) | 1.12 (0.93–1.35) | 1.19 (0.99–1.45) | 0.19 | 1.02 (0.96–1.08) |
| Total Stroke | |||||||
| Events, n | 112 | 125 | 108 | 103 | 109 | ||
| Incidence rate† | 14.6 (12.1–17.6) | 15.3 (12.8–18.2) | 12.8 (10.6–15.5) | 12.1 (10.0–14.7) | 12.9 (10.7–15.5) | ||
| Model 1 HR | 1 (Referent) | 1.07 (0.83–1.38) | 0.91 (0.70–1.19) | 0.86 (0.65–1.13) | 0.94 (0.71–1.24) | 0.36 | 0.95 (0.87–1.04) |
| Model 2 HR | 1 (Referent) | 1.08 (0.83–1.40) | 0.90 (0.69–1.19) | 0.83 (0.62–1.10) | 0.86 (0.65–1.15) | 0.11 | 0.93 (0.84–1.02) |
| Ischemic Stroke | |||||||
| Events, n | 91 | 106 | 93 | 90 | 93 | ||
| Incidence rate† | 11.8 (9.6–14.6) | 12.9 (10.7–15.7) | 11.0 (9.0–13.5) | 10.6 (8.6–13.0) | 11.0 (9.0–13.5) | ||
| Model 1 HR | 1 (Referent) | 1.13 (0.85–1.50) | 0.98 (0.73–1.31) | 0.94 (0.70–1.27) | 1.01 (0.75–1.37) | 0.71 | 0.97 (0.88–1.08) |
| Model 2 HR | 1 (Referent) | 1.13 (0.85–1.51) | 0.96 (0.71–1.29) | 0.89 (0.65–1.20) | 0.90 (0.66–1.23) | 0.22 | 0.94 (0.85–1.04) |
| Hemorrhagic Stroke | |||||||
| Events, n | 21 | 19 | 15 | 13 | 16 | ||
| Incidence rate† | 2.7 (1.8–4.2) | 2.3 (1.5–3.6) | 1.8 (1.1–2.9) | 1.5 (0.9–2.6) | 1.9 (1.2–3.1) | ||
| Model 1 HR | 1.52 (0.78–2.99) | 1.24 (0.63–2.43) | 0.95 (0.47–1.93) | 0.81 (0.39–1.68) | 1 (Referent) | 0.14 | 0.82 (0.64–1.06) |
| Model 2 HR | 1.36 (0.67–2.75) | 1.16 (0.58–2.32) | 0.93 (0.45–1.91) | 0.78 (0.37–1.64) | 1 (Referent) | 0.24 | 0.85 (0.65–1.10) |
Model 1: Hazard ratio (HR) with 95% confidence interval from Cox proportional hazards model adjusted for age (continuous), sex, race and center.
Model 2: Model 1 additionally adjusted for years of education (continuous), smoking status (never, former, current), alcohol intake (continuous), body mass index (continuous), systolic blood pressure (continuous), antihypertensive medication use (yes or no), diabetes status (yes or no), total and HDL cholesterol (continuous).
†
Unadjusted incidence rate per 1000 person-years with 95% confidence interval.