Table 1.
Demographic and clinical characteristics of participants ages 12–19 years with cystatin C (adjusted for age, sex and race/ethnicity) from the SEARCH for Diabetes in Youth Study, stratified by diabetes type, and NHANES 2001–2002 without diagnosed diabetes.
| Clinical characteristics | SEARCH Type 1* N=977 Mean (SE) |
SEARCH Type 2* N=168 Mean (SE) |
NHANES 2001–2002** N=544 Mean (SE) |
|---|---|---|---|
| Age, years | 14.9 (0.07)$& | 16.3 (0.17)$# | 15.5(0.12)#& |
| Diabetes Duration | 3.6 (0.07)& | 2.8 (0.2)# | NA |
| Sex, % Male | 51.3& | 36.3$# | 54.5& |
| Race/Ethnicity (%) | $& | $# | #& |
| White | 76.8 | 19.6 | 62.8 |
| Black | 9.2 | 45.8 | 13.8 |
| Hispanic | 10.2 | 25.6 | 16.8 |
| Other | 3.8 | 8.9 | 6.6 |
| SBP z-score | −0.5 (0.03)& | 0.3 (0.08) $# | −0.3 (0.07)& |
| DBP z-score | 0.1 (0.03) $& | 0.6 (0.07) $# | −0.4 (0.07)#& |
| BMI z-score | 0.7 (0.03) $& | 2.1 (0.05) $# | 0.5(0.06) # & |
| Fasting glucose, mg/dL | 191.7 (2.9) | 169.3 (6.8) | NA |
| HbA1c, % | 8.5 (0.06) $ | 7.9 (0.2) $ | 5.2 (0.01) # & |
| (IFCC units) | (69 mmol/mol) | (63 mmol/mol) | (33 mmol/mol) |
| Albumin/Creatinine ratio (µg/mg)@ | 6.6 (4.4, 12.1) | 7.2 (4.3, 18.8)$ | 6.3 (4.2, 11.2)& |
| Adjusted Cystatin C, mg/L^ | 0.75 (0.004)$& | 0.70 (0.01)$# | 0.85 (0.01)#& |
Restricted to age 12–19, Cystatin C measured, and Type1 or Type 2 Diabetes.
Restricted to age 12–19, Cystatin C measured, and non-diabetic; NHANES values reported incorporate the sampling weights for the complex survey design. SBP Systolic blood pressure; DBP Diastolic blood pressure;
median (25th, 75th percentiles) -Tests performed on log transformed values as data were not normally distributed;
P<0.001 compared with NHANES
P<0.001 compared with SEARCH Type 1
P<0.001 compared with SEARCH Type 2
Adjusted for age, sex, race/ethnicity