Fig. 1.
Overall survival by gene alteration. The unknown group included 177 patients who had a negative test result for EGFR or ALK but were not tested for both. With the use of multiple Cox regression to adjust for Lung-GPA prognosis, year of BM, and smoking history, ALK+ (P<.0001) and EGFR+ (P=.001) patients had longer overall survival than did EGFR/ALK− patients. KRAS+ was not significantly different (P=.45) from EGFR/ALK−. Abbreviations: ALK = anaplastic lymphoma kinase; BM = brain metastases; EFGR = epidermal growth factor receptor; KRAS = Kirsten RNA–associated sarcoma; MST = median survival time.