Table 3.
Multivariable analysis of risk of death and median survival by treatment
| Histology | Treatment
|
|||||
|---|---|---|---|---|---|---|
| WBRT | SRS | WBRT + SRS | S + SRS | S + WBRT | S + WBRT + SRS | |
| Historical control, NSCLC (n=1833) | ||||||
| Risk of death (HR) | 1.00 | 0.62 | 0.54 | 0.48 | 0.48 | 0.39 |
| 95% CI | 0.51–0.74 | 0.46–0.64 | 0.34–0.68 | 0.40–0.57 | 0.27–0.55 | |
| P | <.01 | <.01 | <.01 | <.01 | <.01 | |
| Median survival | 4 | 10 | 13 | 12 | 12 | 12 |
| n (%) | 768 (42%) | 395 (22%) | 339 (18%) | 58 (3%) | 212 (12%) | 61 (3%) |
| Mean GPA | 1.9 | 2.2 | 2.3 | 2.2 | 2.6 | 2.4 |
| Adenocarcinoma overall (n=1521) | ||||||
| Risk of death (HR) | 1.00 | 1.08 | 1.20 | 0.66 | 0.78 | 0.79 |
| 95% CI | 0.92–1.27 | 0.94–1.54 | 0.50–0.88 | 0.58–1.06 | 0.40–1.58 | |
| P | .35 | .15 | <.01 | .11 | .51 | |
| Median survival | 13 | 14 | 10 | 32 | 20 | 20 |
| n (%) | 342 (22%) | 767 (50%) | 139 (9%) | 114 (7%) | 76 (5%) | 13 (1%) |
| Mean GPA | 1.5 | 2.1 | 1.8 | 2.3 | 2.2 | 2.6 |
Abbreviations: GPA = graded prognostic assessment; HR = hazard ratio; NR = not reached; NSCLC = non-small cell lung cancer; S = surgery; SRS = stereotactic radiosurgery; WBRT = whole brain radiation therapy.
Seventy patients had incomplete treatment data and were excluded from the columns in this table. Within each subgroup, risk of death HR, 95% CI, and P values are compared with patients treated with WBRT alone (HR, 1.0), using multiple Cox regression, adjusted for GPA. Median survival is given in months and is based on the Kaplan-Meier method, unadjusted for other factors.