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. Author manuscript; available in PMC: 2018 Aug 2.
Published in final edited form as: J Am Chem Soc. 2017 Jul 20;139(30):10192–10195. doi: 10.1021/jacs.7b04880

Figure 2.

Figure 2

Results of seven replicate IDUP experiments of combined protein and small molecule libraries. Eight DNA barcodes corresponding to bona fide interactions (Bak:Bcl-xL, PKI:PRKX, JQ1:BRD2, JQ1:BRD3, bisX:GSK3α, EA:MAP2K6) enriched (red) out of 32 096 possibilities. KD and IC50 values are for compounds and proteins not linked to DNA. Nonspecific amplification across some protein barcodes may arise from poor expression of those targets (see Figure S2).