Table 3.
Extended multivariable analysis of predictive significance of CCL2 and IL-10 for rate of change in FVC% in GENISOS cohort *
| Cytokine | b | 95% CI | p-value |
|---|---|---|---|
| Time: CCL2 | −0.69 | (−1.24; −0.15) | 0.013 |
| Time: IL10 | 0.28 | (0.09; 0.47) | 0.004 |
| Time | 1.41 | (−0.98; 3.80) | 0.248 |
| CCL2 | −2.79 | (−7.07; 1.50) | 0.202 |
| IL10 | −2.19 | (−3.76; −0.63) | 0.006 |
| Diffuse | −5.24 | (−10.49; 0.01) | 0.051 |
| Immunosuppression | −8.44 | (−13.69; −3.20) | 0.002 |
| Topo I | −4.92 | (−11.79; 1.95) | 0.160 |
| LnCRP | −3.23 | (−4.96; −1.51) | <0.001 |
Adjusted for age at enrollment, gender, and African American race