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. Author manuscript; available in PMC: 2018 Jan 31.
Published in final edited form as: Nat Neurosci. 2017 Jul 31;20(9):1209–1212. doi: 10.1038/nn.4612

Figure 1.

Figure 1

ZIKV infection results in apoptosis of somatosensory neurons in mouse peripheral nervous system. Mouse embryos were infected by intraventricular injection of 650 PFUs of ZIKVSZ01 or mock at E13.5 and analyzed at P1. (a) Representative images of mouse dorsal root ganglia (DRG)-sections stained with the indicated antibodies. White arrowheads, ZIKV-infected DRG neurons. (b) Sample images of DRG-sections stained with the indicated antibodies. Cleaved-Caspase 3, cl-Casp3. Yellow arrowheads, ZIKV-infected apoptotic DRG neurons. Scale bars, 20 μm. (c) The percentage of apoptotic neurons in the mock-treated and ZIKV-infected DRGs. All error bars represent mean ± s.e.m. (****P < 0.0001; n.s., not significant; unpaired Student’s t-test; n = 10 for Mock-treated, n = 10 for ZIKV-infected). The n represents the number of analyzed DRGs from 4 pups.