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. 2016 Nov 15;23(2):422–433. doi: 10.1038/mp.2016.192

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Meta-analysis of epigenome-wide association of alcohol intake in European ancestry (EA) whole-blood samples: the Manhattan plot (top) and the volcano plot (bottom). The DNA methylation proportion was the outcome variable, grams alcohol consumed per day (g per day) was the predictor variable, adjusting for age, sex, body mass index, technical covariates and white blood cell counts. The inverse-variance weighted random-effects model was performed in meta-analysis using all whole blood DNA samples of EA.