Table 1. Characteristics of the study participants.
| Study | N | Men (%) | Age (years), mean (s.d.) | BMI mean (s.d.) | Current smoking (%) | g per day, Median (min, max) | Non-drinkers (%) | Light drinkers (%) | At-risk drinkers (%) | Heavy drinkers (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| European ancestry whole blood (n=9643) | ||||||||||
| CHS | 185 | 84 (45) | 76 (5) | 27 (5) | 16 (9) | 0 (0, 99) | 104 (56) | 59 (32) | 7 (4) | 15 (8) |
| EPIC-Norfolk | 1275 | 650 (51) | 60 (9) | 27 (4) | 191 (15) | 3 (0, 98) | 271 (21) | 865 (68) | 79 (6) | 60 (5) |
| FHS | 2427 | 1095 (45) | 66 (9) | 28 (5) | 304 (13) | 4 (0, 181) | 693 (29) | 1260 (52) | 280 (11) | 194 (8) |
| InCHIANTI | 499 | 225 (45) | 63 (16) | 27 (4) | 94 (19) | 8 (0, 161) | 106 (21) | 265 (53) | 70 (14) | 58 (12) |
| KORA F4 | 1797 | 877 (49) | 60 (9) | 28 (5) | 262 (15) | 7 (0, 150) | 534 (29) | 751 (42) | 282 (16) | 230 (13) |
| LBC1936 | 920 | 465 (51) | 70 (1) | 28 (4) | 103 (11) | 7 (0,158) | 181 (20) | 574 (62) | 104 (11) | 61 (7) |
| NAS | 623 | 623 (100) | 72 (7) | 28 (4) | 27 (4) | 6 (0, 93) | 148 (24) | 385 (62) | 52 (8) | 38 (6) |
| PIVUS | 818 | 412 (50) | 70 (0.2) | 27 (4) | 75 (9.2) | 6.7 (0, 61) | 142 (17) | 639 (78) | 32 (4) | 5 (1) |
| RS | 502 | 241 (48) | 58 (7) | 27 (5) | 137 (27) | 14 (0, 88) | 10 (2) | 366 (73) | 84 (17) | 42 (8) |
| TwinsUK | 597 | 0 (0) | 56 (9) | 27 (5) | 57 (10) | 2 (0,59) | 189 (31) | 375 (63) | 22 (4) | 11 (2) |
| African ancestry whole blood (n=2423) | ||||||||||
| ARIC | 2003 | 721 (36) | 56 (6) | 30 (6) | 490 (24) | 0 (0, 301) | 1519 (76) | 67 (3) | 69 (3) | 348 (17) |
| CHS | 190 | 66 (35) | 73 (5) | 29 (5) | 29 (15.3) | 0 (0, 74) | 123 (65) | 61(32) | 2 (1) | 4 (2) |
| GTP | 230 | 76 (33) | 42 (12) | 32 (8) | 74 (39) | 14 (0,143) | 45 (20) | 113 (49) | NA | 72 (31) |
| CD14+ monocytes (n=1251) | ||||||||||
| MESA | 1251 | 606 (48) | 60 (9) | 30 (6) | 114 (9%) | 8 (0, 191) | 691 (55) | 444 (36) | 65 (5) | 51 (4) |
Abbreviations: ARIC, The Atherosclerosis Risk in Communities study; BMI, body mass index; CHS, The Cardiovascular Health Study; EPIC-Norfolk, The European Prospective Investigation into Cancer-Norfolk study; FHS, The Framingham Heart Study; GTP, The Grady Trauma Project; KORA F4, The Cooperative Health Research in the Region of Augsburg study; InCHIANTI, Invecchiare in Chianti; LBC1936, The Lothian Birth Cohort 1936; MESA, The Multi-Ethnic Study of Atherosclerosis; NAS, The Normative Aging Study; PIVUS, The Prospective Investigation of the Vasculature in Uppsala Seniors Study; RS, The Rotterdam Study; TwinsUK, The TwinsUK Study. The drinking categories were defined based on grams of alcohol consumed per day (g per day): non-drinkers, g per day=0; light drinkers, 0<–≤28 g per day in men and 0<–≤14 g per day in women; at-risk drinkers, 28<–<42 g per day in men and 14<–<28 g per day in women; and heavy drinkers, g per day ≥42 in men and ≥28 in women. The Monocyte samples included mixed samples of European (47%), African (21%) and Hispanic (32%) ancestries.