Table 1.
DDX3 expression and other clinicopathological characteristics in breast cancer in BRCA1 or BRCA2 germline mutation carriers as compared to sporadic breast cancers
| Sporadic | BRCA1 | P value | BRCA2 | P value | |
|---|---|---|---|---|---|
| DDX3 expression [n (%)] | 0.337a | 0.624a | |||
| Absent | 3 (1) | 0 | 0 | ||
| Weak | 34 (13) | 19 (18) | 5 (17) | ||
| Moderate | 148 (56) | 59 (57) | 18 (62) | ||
| Strong | 80 (30) | 25 (24) | 6 (21) | ||
| Age [median (IQR)] | 58 (18) | 40 (11.5) | <0.001b | 50 (11) | <0.001b |
| B&R grade [n (%)] | <0.001 | 0.014a | |||
| 1 | 45 (17) | 2 (2) | 0 | ||
| 2 | 99 (37) | 15 (16) | 8 (31) | ||
| 3 | 121 (46) | 78 (82) | 18 (69) | ||
| Missing | 0 | 0 | 1 | ||
| MAI [median (IQR)] | 12 (18) | 25 (25) | <0.001b | 17 (13) | 0.110a |
| Missing | 0 | 13 | 3 | ||
| Histological type [n (%)] | 0.064 | 0.667a | |||
| Invasive ductal carcinoma | 225 (85) | 80 (84) | 25 (93) | ||
| Invasive lobular carcinoma | 24 (9) | 4 (4) | 2 (7) | ||
| Other | 15 (6) | 11 (12) | 0 | ||
| Missing | 1 | 8 | 2 | ||
| Tumor size (cm) [median (IQR)] | 2 (2) | 2 (2) | 0.924b | 1 (1) | 0.029b |
| Missing | 22 | 26 | 6 | ||
| ER [n (%)] | <0.001 | 1 | |||
| Negative | 50 (19) | 76 (77) | 5 (19) | ||
| Positive | 215 (81) | 23 (23) | 22 (81) | ||
| Missing | 0 | 4 | 2 | ||
| PR [n (%)] | <0.001 | 0.171 | |||
| Negative | 87 (33) | 81 (83) | 13 (48) | ||
| Positive | 177 (67) | 17 (17) | 14 (52) | ||
| Missing | 1 | 5 | 2 | ||
| HER2 [n (%)] | 0.828 | 1a | |||
| Negative | 243 (92) | 94 (93) | 26 (93) | ||
| Positive | 22 (8) | 7 (7) | 2 (7) | ||
| Missing | 0 | 2 | 1 | ||
| Molecular classification [n (%)] | <0.001a | 0.897a | |||
| Luminal A | 208 (78) | 20 (21) | 21 (81) | ||
| Luminal B | 12 (5) | 4 (4) | 1 (4) | ||
| HER2 overexpressing | 10 (4) | 4 (4) | 0 | ||
| Basal-like | 35 (13) | 67 (71) | 4 (15) | ||
| Unclassified | 0 | 0 | 0 | ||
| Missing |
P value calculated by Chi-square test unless otherwise indicated
n number, B&R Bloom and Richardson, MAI mitotic activity index, IQR interquartile range
a
Fisher exact test
b
Mann–Whitney U test