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. 2017 Aug 15;130(16):2682–2695. doi: 10.1242/jcs.201731

Fig. 6.

Fig. 6.

Effect of properties of sterols on PLAP and TF endocytosis. Each dot represents each one of the sterols in the categories shown and horizontal gray bars are average (mean) level of the endocytosis in each category. (A–E) Relationships between sterol properties (x-axis) and PLAP endocytosis level (y-axis, percentage of cholesterol replenished). (F–J) Relationships between sterol properties (x-axis) and TF endocytosis level (y-axis, percentage of cholesterol replenished). (A) Relationship between raft-forming ability (high, intermediate and low) and PLAP endocytosis. (B) Effect of the presence (WITH) or absence (W/O) of the 3β-OH group on PLAP endocytosis. (C) Effect of having both raft-promoting ability and the 3β-OH group upon the PLAP endocytosis. (D) Effect of the double bond between carbons 5 and 6 in the B-ring upon PLAP endocytosis. (E) Relationship between cholesterol tail structure and PLAP endocytosis. (F) Relationship between raft-forming ability and TF endocytosis. (G) Effect of the presence or absence of the 3β-OH group and TF endocytosis. (H) Effect of having both raft-promoting ability and the 3β-OH group upon TF endocytosis. (I) Effect of the double bond between carbons 5 and 6 in the B-ring upon TF endocytosis. (J) Relationship between cholesterol tail structure and TF endocytosis.