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. 2017 Jun 22;6(8):1130–1136. doi: 10.1242/bio.024562

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Effects of Tec treatment on surgically induced OA. (A) Knee joints were harvested at 6 weeks postsurgery and analyzed histologically via Safranin O−fast green staining. Representative images are shown. (B) OA of the femoral and tibial cartilage was scored histologically using the OARSI scoring system at 8 weeks postsurgery. (C) Immunohistochemical staining of Aggrecan Neoepitope and MMP-3. Data are expressed as mean±s.e.m. (n=10). *P<0.05, **P<0.01, compared to treatment with saline. Scale bars: 50 μm.